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Neonatal Neuro Imaging

ADC MapR2 Map
(i)(ii)

ADC Map (i) and R2 Map (ii) for an infant diagnosed with severe HI

ADC MapR2 Map
(iii)(iv)

ADC map (iii) and R2 map (iv) for an infant with mild HI

Apparent Diffusion Coefficient (ADC) map of an infant born prematurely and scanned at term age. The apparent diffusion coefficient is a measure of the mobility of water molecules within tissue. Cerebral Spinal Fluid (CSF) has a high ADC value because there are no restrictions to the motion of the water molecules. In brain tissue the motion of water molecules is restricted by membranes, macromolecules etc, which reduce ADC value.

Fractional Anisotropy
FA

Fractional Anisotropy (FA) map of same infant. FA is a measure of the directional dependence of the motion of water molecules. Bright areas correspond to fibre tracts within the brain.

Colored FAColored FA
Colored FA (i) Colored FA (ii)

Colored FA (i) :- Colour Fractional Anisotropy (FA) map of same infant. The intensity of the image is scaled by the FA map. The colours on the image correspond to the principle direction of the water motion. Blue is motion in/out of the plane of the image, green is motion up/down and red represents motion left/right. Colored FA (ii) :- Colour Fractional Anisotropy of same infant, from a slice higher in the brain.

ADC Map

ADC Map

ADC Map of whole volume

ADC Map of whole volume

Multi-slice display of the ADC values of an infant born prematurely and scanned at term age.

Preterm Volume

Preterm Volume

MP-RAGE volumetric image of a pre-term infant. It can be noted that the contrast between the white and gray matter is reversed compared to adult. Additionally, the degree of folding in the brain is markedly reduced compared to the adult image. A research project was conducted for preterm infant with a bleed in the brain. Brain volume differences between infants with and without a bleed were investigated.

Term Volume

Term Volume

MP-RAGE volumetric image of a term aged infant.

Adult Volume

Adult Volume

MP-RAGE volumetric image of a young adult. 3D volumetric images can be used to quantify the volume of brain tissue (white matter, gray matter). A research project at the 3.0T MRI scanner has quantified white and gray matter tissue volume differences in children with Autism and Tourette Syndrome.

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